Natural products have become a major source for the generation of lead compounds for drug discovery research.Â Since conventional NMR employs either 5 or 3 mm tubes, most laboratories need low milligram quantities of sample to acquire all of the necessary homo- and heteronuclear correlations for full structure elucidation.Â If compounds are mass limited, as is the case in natural products drug discovery, obtaining low-milligram quantities of sample requires multiple steps of separation needing weeks or even months of time. With a capillary based microlitre volume flow cell, the acquisition of NMR spectra on the samples in trace quantities is dramatically improved.Â With microNMR, structure elucidation can be achieved within a fraction of the time needed as compared to conventional natural products chemistry.Â The possibility of working with such small quantities is an important step forward in utilising natural products in drug discovery research.Â This technique open doors, enabling chemists to readily discover bioactive components among the minor constituents of natural resources.
Natural Products Downloads
CapNMR Probes give you:
Prof. John Blunt, University of Canterbury, Christchurch, New Zealand