One-Minute NMR Automation

Boost Productivity in Your Department!

One-Minute NMR

Efficient NMR Automation
One-Minute NMR combines feature-rich sample management with supreme ease of use. Save time and money while enhancing sensitivity and spectral quality.  For increased functionality at a remarkable value, nothing else compares.

  • Utilize all of your magnet time

    Run overnight or over the weekend and get more work done!

  • Use standard vials and microplates

    Run LC-MS fractions directly without the time and cost of tube filling.

  • Login Samples from any browser, tablet or phone on your network

    Login samples in about a minute…

  • Optimize S/N with Zero Dispersion

    Optimize signal by exactly matching magnet active volume with reproducible injections.

  • Recollect Precious Samples

    Samples can be returned to their original location or collected in a new well or vial.

  • Automate cleaning protocols

    One-Minute NMR can concentrate analytes, exchange to deuterated solvents and then clean up after itself!

One-Minute NMR

Automation for Medicinal Chemists

Find New Molecular Entities
Find New Molecular Entities

Run NMR on Your Existing LC-MS Fractions


Log in Samples Rapidly from Any Browser, Table or Phone


Log in Samples Rapidly from Any Browser, Table or Phone

1m - Single Page

Net More Results


Featured Speaker

Dr. Anna Codina

This e-seminar features Dr. Anna Codina, then resident at the Pfizer Ltd Sandwich (UK) research facility. Prior to Pfizer, Dr. Codina had affiliation with the Laboratory of Molecular Biology Medical Research Council in Cambridge, UK – a cornerstone of biological systems and molecular structure advances that include the proposal of a double helical structure of DNA and the solution of structures of myoglobin and haemoglobin to atomic resolution. This e-seminar, entitled “Cap and CASE: a step forward towards automatic structure elucidation” involves investigations into modern approaches to elucidation involving NMR.

Reference Customer

Medicinal Chmist

NMR Structure Elucidation

Anna Codina - 1224d64

The Protasis CapNMR DPC Probe has dual 10uL flowcells and so can run two NMR samples at the same time (by interleaving). This unique, patented innovation was developed by Protasis under Pfizer’s Strategic Alliance program and is deployed at Pfizer MedChem labs in Groton, CT and La Jolla, CA.


Support Your Entire Department!

Log in your sample and walk away.  One-Minute NMR will run your sample.  Results go to your Inbox.


Go to our Web Store to order a free sample kit!

One-Minute NMR Newsletter

Boost Productivity in Your Department!

One-Minute NMR Newsletter / Brochure

Succeed with Open-Access HT-NMR

Flexible.  Reliable.  Efficient.  Connected.  Secure.

Find New Molecular Entities
Find New Molecular Entities
Press Release

Protasis Confirms New Molecules for Drug Discovery

New Product Helps Synthesis Chemists in Pharmaceutical Companies Answer the Critical Question, “Did I Make What I Thought I Made?”

Protasis Corporation (Marlboro, Mprotasis_enlargeA, announces the release of its new Discovery High Throughput Structure Confirmation (HTSC) NMR Workstation, an automated MicroFlow NMR™ system for medicinal chemists, for use with Bruker or Varian spectrometers and third party structure confirmation and data archiving software. The turnkey system uses the Protasis/MRM CapNMR™ probe, Protasis One-Minute NMR™ software, the CTC/Leap PAL from Leap Technologies (Carrboro, NC, liquid handler, highpressure pumps and proprietary web-based software for control. This medicinal chemistry structure confirmation system was developed and fine-tuned in long-term collaborations with several pharmaceutical companies including Pfizer, Merck, Genomics Institute (of the Novartis Research Foundation), several academic institutions including the University of Illinois, Princeton University and the University of Georgia, as well as the NMR software firm ACD/Labs (Toronto, Ontario,, for both high-throughput microplate and open-access vial-based analysis.  The Discovery HTSC-NMR Workstation brings the ease of mass spectrometer-style liquid handling and software to NMR analysis. The components of the system have been selected and optimized for the medicinal chemistry laboratory.

1m - Single PageThe Protasis One-Minute NMR control system reduces operator intervention requirements of Varian and Bruker software and hardware by automating sample lists; monitoring system suitability and performance, and reporting and automatically correcting common software and electronic problems of these systems. Medicinal chemists now have the ability to import sample lists from spread sheets or log-in through a few mouse clicks. E-mail reports are generated for groups of samples as they are finished. The control system provides an open interface to any structure confirmation and back-end processing software, and uses a built-in web-based interface to ACD/Labs’ 1D and 2D Structure Verification processing and databasing platform. Once processed, stored NMR results, molecular structures, and functional group assignments can be conveniently accessed through HTML links to use the full power of ACD/Labs NMR Spectrum Manager.

Enhanced NMR detection is provided by the Protasis CapNMR probe which enables workflow improvement by eliminating the transfer of sample to tubes, dramatically shortening analysis times, reducing sample mass to just a few micrograms, and reducing sample volume requirements to as little as 5 microliters from typical library samples. Customers can automatically recover all of their sample or dispose of the miniscule amount taken away, thereby eliminating a second trip back to the NMR lab. The CapNMR probe is available with one or two flow-cells for hydrogen, nitrogen, and/or carbon detection, and is capable of running all standard NMR experiments.

The CTC/Leap PAL liquid handler uses a syringe-only sample handling injection system with a very low dead volume and zero-carryover. This liquid handler was originally designed for demanding mass spectrometer applications and Protasis has found that it mates well with the low volume requirements of the CapNMR probe. The One-Minute NMR solvent handling and conditioning system delivers samples through capillary tubing at high pressure with minimal dispersion to the CapNMR probe using filtered and degassed solvents. The helium-blanketed solvent reservoirs eliminate changes in solvent from atmospheric gasses and moisture over extended time periods.

One-Minute NMR has been proven itself in comprehensive trials in both industrial and academic laboratories by running more than 250,000 real samples over the past two years with excellent results. Protasis is currently visiting Medicinal Chemistry departments, delivering focused seminars on CapNMR structure confirmation and taking orders for Discovery HTSC-NMR Workstations to be installed in the first half of 2007. Typical

More Information

OAHT-NMR Documents

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One-Minute NMR Blog Articles

Boost Productivity in Your Department!

One-Minute NMR Platform


One-Minute NMR Overview

Now you can obtain the highest quality NMR spectra automatically with less sample in less time:

  • LEAP & Tower Side 2 HQHighest mass sensitivity (micrograms)
  • One minute fluidic cycle time
  • One minute proton spectra
  • 2D spectra in a few hours
  • One-Minute NMR Software
  • Web-based with the same browser interface for Agilent, Bruker, Varian INOVA and JEOL
  • Load from standard laboratory consumables;
    • low volume vials
    • 96-well plates
    • 384-well plates, etc.
  • Downsize to MicroFlow NMR and save on sample utilization, reagent cost, tube cost and magnet time

Who uses NMR Automation?

  • Mass-limited researchers building full libraries of 1D and 2D spectra
  • Multi-user facilities that want improved NMR productivity
  • Biofluids analysts need higher throughout for serum and urine
  • Facility managers wanting to breathe new life into existing 400 MHz NMR systems
  • Anyone that wants automated use standard microplates or vials

We believe that end-user collaboration is key to creation of quality products that deliver the results you need. 

The One-Minute NMR system was designed by a team of NMR spectroscopists, software developers and fluidic engineers.  Participating NMR users helped out by specifying their needs and providing feedback as development began. The resulting modular, expandable Discovery Platform can keep up with your  sample demand today and can evolve to meet your laboratory’s changing needs and increasing workloads.  One-Minute NMR delivers advanced features across the discovery and development value chain, from natural product chemists to biofluids analysis to trace impurity identification.  Every chemist and their managers will appreciate the productivity boost and convenience of walk-away, unattended operation, with special support for overnight samples.  When you consider the reduced sample prep for new samples, reduced sample utilization from existing libraries, reduced reagent and solvent consumption, elimination of the cost and climbing of tubes. and improved magnet utilization due to faster spectral acquisition, this is a system that easily justifies itself in any NMR facility with multiple users or many samples.

Protasis Discovery Platforms deliver amplified performance in software and hardware, applied to real-world customers and samples.


One-Minute NMR Requirements

Operating System

Windows XP Professional (Legacy Support for Existing Customers)

Windows 7, 8 or 8.1


4GB (minimum)

Hard Drive

1TB (typical installation)


Windows Professional is required. .NET Framework and SQ Server run-time are used.

Compatible NMR Operating Systems


Windows (Bruker)

Compatible Spectrometers






Internet Explorer 8 should be used for Windows XP systems.

Internet access is required for the installation.

BU-CMLD Loads 54-Vial Tray

Open-Access NMR


“The walk-up spectrometers are accounted in 10-minute increments and can be used reserved for blocks of time ranging from 10 minutes to 24 hours depending on the time of day and whether the usage is on a weekend or weekday. To gain access to these instruments, please Request a xxxx CIC Account. After we have evaluated your needs, CIC staff will create your accounts and schedule training sessions as appropriate.”


  1. Log in your sample from any browser, tablet or smartphone.
  2. Bring the sample to the NMR system and place it in the reserved tray location.
  3.  Click the Run button. Walk away.  Your results will be waiting in your Inbox.

/by David Strand


/by David Strand


/by David Strand


/by David Strand